Literature summary extracted from

Ogiyama, T.; Yamaguchi, M.; Kurikawa, N.; Honzumi, S.; Yamamoto, Y.; Sugiyama, D.; Takakusa, H.; Inoue, S.I.
Identification of a novel hormone sensitive lipase inhibitor with a reduced potential of reactive metabolites formation (2017), Bioorg. Med. Chem., 25, 2234-2243 .

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
3.1.1.79	expression in Sf9 cell	Homo sapiens

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.1.1.79	(5-chloro-2-[([6-[4-(trifluoromethyl)phenoxy]pyridin-3-yl]carbonyl)amino]phenyl)boronic acid	potent HSL inhibitor with a significantly reduced bioactivation potential. Oral administration of compound exhibit an antilipolytic effect on rats at 3 mg/kg	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.1.1.79	Homo sapiens	-	-	-

IC50 Value

EC Number	IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
3.1.1.79	0.000002	-	pH 7.3, 37°C	Homo sapiens	(5-chloro-2-[([6-[4-(trifluoromethyl)phenoxy]pyridin-3-yl]carbonyl)amino]phenyl)boronic acid

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Release 2023.1 (January 2023)